Antipsychotic drugs suppress the AKT/NF-&#954;B pathway and regulate the differentiation of T-cell subsets.

Chen, Mao-Liang; Tsai, Tzung-Chieh; Lin, Yi-Yin; Tsai, Ya-Min; Wang, Lu-Kai; Lee, Ming-Cheng; Tsai, Fu-Ming

Antipsychotic drugs suppress the AKT/NF-κB pathway and regulate the differentiation of T-cell subsets.

Chen, Mao-Liang; Tsai, Tzung-Chieh; Lin, Yi-Yin; Tsai, Ya-Min; Wang, Lu-Kai; Lee, Ming-Cheng; Tsai, Fu-Ming.

Affiliation

Chen ML; Department of Research, Buddhist Tzu Chi General Hospital, Taipei Branch, New Taipei City, Taiwan.

Immunol Lett ; 140(1-2): 81-91, 2011 Oct 30.

Article in En | MEDLINE | ID: mdl-21763349

Subject(s)

Antipsychotic Agents/therapeutic use; CD4-Positive T-Lymphocytes/drug effects; Schizophrenia/drug therapy; T-Lymphocyte Subsets/drug effects; Antipsychotic Agents/pharmacology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD4-Positive T-Lymphocytes/pathology; Cell Differentiation/drug effects; Cells, Cultured; Clozapine/pharmacology; GATA3 Transcription Factor/metabolism; Haloperidol/pharmacology; Humans; NF-kappa B/metabolism; Oncogene Protein v-akt/metabolism; Risperidone/pharmacology; Signal Transduction; T-Box Domain Proteins/metabolism; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; T-Lymphocyte Subsets/pathology; Th1-Th2 Balance/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Antipsychotic Agents / CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets Limits: Humans Language: En Journal: Immunol Lett Year: 2011 Document type: Article

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