P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

Brambilla, Daria; Zamboni, Silvia; Federici, Cristina; Lugini, Luana; Lozupone, Francesco; De Milito, Angelo; Cecchetti, Serena; Cianfriglia, Maurizio; Fais, Stefano

Brambilla, Daria; Zamboni, Silvia; Federici, Cristina; Lugini, Luana; Lozupone, Francesco; De Milito, Angelo; Cecchetti, Serena; Cianfriglia, Maurizio; Fais, Stefano.

Affiliation

Brambilla D; Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.

Int J Cancer ; 130(12): 2824-34, 2012 Jun 15.

Article in En | MEDLINE | ID: mdl-21780101

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Cytoskeletal Proteins/metabolism; Osteosarcoma/drug therapy; Osteosarcoma/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis; Bone Neoplasms/drug therapy; Bone Neoplasms/metabolism; Cell Line, Tumor; Cell Membrane/metabolism; Cytoskeletal Proteins/genetics; Drug Resistance, Neoplasm/genetics; G(M1) Ganglioside/metabolism; Humans; Membrane Microdomains

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteosarcoma / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Cytoskeletal Proteins Limits: Humans Language: En Journal: Int J Cancer Year: 2012 Document type: Article

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