Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress.

Jerkic, Mirjana; Kabir, Mohammed G; Davies, Adrienne; Yu, Lisa X; McIntyre, Brendan A S; Husain, Nasir W; Enomoto, Masahiro; Sotov, Valentin; Husain, Mansoor; Henkelman, Mark; Belik, Jaques; Letarte, Michelle

Jerkic, Mirjana; Kabir, Mohammed G; Davies, Adrienne; Yu, Lisa X; McIntyre, Brendan A S; Husain, Nasir W; Enomoto, Masahiro; Sotov, Valentin; Husain, Mansoor; Henkelman, Mark; Belik, Jaques; Letarte, Michelle.

Affiliation

Jerkic M; Molecular Structure and Function Program, Hospital for Sick Children, 555 University Ave., Toronto, ON, Canada M5G 1X8.

Cardiovasc Res ; 92(3): 375-84, 2011 Dec 01.

Article in En | MEDLINE | ID: mdl-21859819

Subject(s)

Activin Receptors, Type I/deficiency; Blood Pressure; Hypertension, Pulmonary/metabolism; Lung/blood supply; Oxidative Stress; Pulmonary Artery/metabolism; Reactive Oxygen Species/metabolism; Activin Receptors, Type I/genetics; Activin Receptors, Type II; Age Factors; Animals; Antihypertensive Agents/pharmacology; Antioxidants/pharmacology; Arterioles/metabolism; Arterioles/physiopathology; Blood Pressure/drug effects; Catalase/metabolism; Cyclic N-Oxides/pharmacology; Dose-Response Relationship, Drug; Heterozygote; Hypertension, Pulmonary/genetics; Hypertension, Pulmonary/pathology; Hypertension, Pulmonary/physiopathology; Hypertension, Pulmonary/prevention & control; Hypertrophy, Right Ventricular/genetics; Hypertrophy, Right Ventricular/metabolism; Hypertrophy, Right Ventricular/physiopathology; Mice; Mice, Knockout; NADPH Oxidases/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Oxidative Stress/drug effects; Prostaglandin-Endoperoxide Synthases/metabolism; Pulmonary Artery/pathology; Pulmonary Artery/physiopathology; Spin Labels; Superoxide Dismutase/metabolism; Vasodilation; Vasodilator Agents/pharmacology; Ventricular Function, Right; Ventricular Pressure

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Pulmonary Artery / Blood Pressure / Reactive Oxygen Species / Oxidative Stress / Activin Receptors, Type I / Hypertension, Pulmonary / Lung Language: En Journal: Cardiovasc Res Year: 2011 Document type: Article

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