The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts.

Mnonopi, Nandipha; Levendal, Ruby-Ann; Davies-Coleman, Michael T; Frost, Carminita L

Mnonopi, Nandipha; Levendal, Ruby-Ann; Davies-Coleman, Michael T; Frost, Carminita L.

Affiliation

Mnonopi N; Department of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth, 6031 South Africa.

J Ethnopharmacol ; 138(1): 67-75, 2011 Oct 31.

Article in En | MEDLINE | ID: mdl-21893184

Subject(s)

Anti-Inflammatory Agents/pharmacology; Anticoagulants/pharmacology; Diterpenes/pharmacology; Lamiaceae/chemistry; Plant Extracts/pharmacology; Platelet Aggregation Inhibitors/pharmacology; Animals; Anti-Inflammatory Agents/isolation & purification; Anti-Inflammatory Agents/therapeutic use; Anticoagulants/isolation & purification; Anticoagulants/therapeutic use; Blood Coagulation/drug effects; Calcium/metabolism; Chemokine CCL5/metabolism; Diterpenes/isolation & purification; Diterpenes/therapeutic use; Dose-Response Relationship, Drug; Fibrin/biosynthesis; Fibrin Fibrinogen Degradation Products/biosynthesis; Fibrinogen/metabolism; Fibrinolytic Agents/isolation & purification; Fibrinolytic Agents/pharmacology; Fibrinolytic Agents/therapeutic use; Glycoproteins/metabolism; Inflammation/drug therapy; Inflammation/etiology; Inflammation/metabolism; Male; Obesity/complications; Obesity/drug therapy; Obesity/metabolism; Partial Thromboplastin Time; Phytotherapy; Plant Extracts/chemistry; Plant Extracts/therapeutic use; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/isolation & purification; Platelet Aggregation Inhibitors/therapeutic use; Rats; Rats, Wistar; Thromboxanes/biosynthesis; Tumor Necrosis Factor-alpha/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platelet Aggregation Inhibitors / Plant Extracts / Lamiaceae / Diterpenes / Anti-Inflammatory Agents / Anticoagulants Type of study: Etiology_studies / Prognostic_studies Language: En Journal: J Ethnopharmacol Year: 2011 Document type: Article

Fulltext

XML

PubMed Links

Search on Google