Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection.

Kok, Wai Ling; Denney, Laura; Benam, Kambez; Cole, Suzanne; Clelland, Colin; McMichael, Andrew J; Ho, Ling-Pei

Kok, Wai Ling; Denney, Laura; Benam, Kambez; Cole, Suzanne; Clelland, Colin; McMichael, Andrew J; Ho, Ling-Pei.

Affiliation

Kok WL; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.

J Leukoc Biol ; 91(3): 357-68, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22003207

Subject(s)

Inflammation/immunology; Influenza A virus/immunology; Lung/immunology; Monocytes/immunology; Natural Killer T-Cells/immunology; Orthomyxoviridae Infections/immunology; Orthomyxoviridae Infections/pathology; Animals; Antibodies, Blocking/administration & dosage; Antibodies, Blocking/immunology; Antigens, CD1d/metabolism; Antigens, Ly/metabolism; Chemokine CCL2/immunology; Chemokine CCL2/metabolism; Humans; Immunophenotyping; Inflammation/metabolism; Inflammation/pathology; Lung/metabolism; Lung/pathology; Lymphocyte Activation/immunology; Macrophages/immunology; Macrophages/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes/pathology; Monocytes/virology; Orthomyxoviridae Infections/mortality; Respiratory Mucosa/immunology; Respiratory Mucosa/metabolism; Respiratory Mucosa/virology

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Influenza A virus / Monocytes / Orthomyxoviridae Infections / Natural Killer T-Cells / Inflammation / Lung Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Leukoc Biol Year: 2012 Document type: Article

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