The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Ahmed, Neesar; Zeng, Minghui; Sinha, Indrajit; Polin, Lisa; Wei, Wei-Zen; Rathinam, Chozhavendan; Flavell, Richard; Massoumi, Ramin; Venuprasad, K

Ahmed, Neesar; Zeng, Minghui; Sinha, Indrajit; Polin, Lisa; Wei, Wei-Zen; Rathinam, Chozhavendan; Flavell, Richard; Massoumi, Ramin; Venuprasad, K.

Affiliation

Ahmed N; Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Nat Immunol ; 12(12): 1176-83, 2011 Nov 06.

Article in En | MEDLINE | ID: mdl-22057290

Subject(s)

Cysteine Endopeptidases/metabolism; Inflammation/enzymology; MAP Kinase Kinase Kinases/metabolism; Ubiquitin-Protein Ligases/metabolism; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Cell Line, Transformed; Cell Line, Tumor; Cysteine Endopeptidases/genetics; Deubiquitinating Enzyme CYLD; Enzyme Activation/genetics; HEK293 Cells; Humans; Inflammation Mediators/metabolism; Macrophages/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Neoplasms/genetics; Neoplasms/metabolism; Neoplasms/mortality; Neoplasms/pathology; Protein Binding; Sequence Alignment; Ubiquitin-Protein Ligases/genetics; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / MAP Kinase Kinase Kinases / Ubiquitin-Protein Ligases / Inflammation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Immunol Year: 2011 Document type: Article

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