A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo.

Rahman, Mahbuba; Chan, Annie P K; Tang, Michelle; Tai, Isabella T

Rahman, Mahbuba; Chan, Annie P K; Tang, Michelle; Tai, Isabella T.

Affiliation

Rahman M; Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada.

PLoS One ; 6(11): e26390, 2011.

Article in En | MEDLINE | ID: mdl-22069448

Subject(s)

Breast Neoplasms/prevention & control; Caspase 8/metabolism; Colorectal Neoplasms/prevention & control; Drug Resistance, Neoplasm; Osteonectin/metabolism; Pancreatic Neoplasms/prevention & control; Peptide Fragments/pharmacology; Proto-Oncogene Proteins c-bcl-2/metabolism; Animals; Apoptosis; Blotting, Western; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Caspase 8/genetics; Caspase Inhibitors; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorouracil/therapeutic use; Humans; Immunoenzyme Techniques; Immunoprecipitation; Mice; Mice, Nude; Mutagenesis, Site-Directed; Osteonectin/antagonists & inhibitors; Osteonectin/genetics; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/metabolism; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/genetics; RNA, Small Interfering/genetics; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Pancreatic Neoplasms / Peptide Fragments / Breast Neoplasms / Colorectal Neoplasms / Osteonectin / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-bcl-2 / Caspase 8 Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: PLoS One Year: 2011 Document type: Article

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