PON1 Q192R and clopidogrel: a case of the winner's curse or inadequate replication?
Clin Pharmacol Ther
; 90(6): 771-4, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-22089342
ABSTRACT
The antiplatelet drug clopidogrel is one of the most commonly prescribed drugs in the world, but there is wide interpatient variability in its antiplatelet effects. The majority of this variation is due to genetic effects, but there is controversy over which genetic variants are important and their relative contribution. This controversy may stem from the genetic association research paradigm, which casts the "winner's curse."
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Genetic Variation
/
Ticlopidine
/
Cardiovascular Diseases
/
Aryldialkylphosphatase
/
Genetic Association Studies
/
Myocardial Infarction
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Pharmacol Ther
Year:
2011
Document type:
Article