Escalated lymphodepletion followed by donor lymphocyte infusion can induce a graft-versus-host response without overwhelming toxicity.

Guillaume, T; Gaugler, B; Chevallier, P; Delaunay, J; Ayari, S; Clavert, A; Rialland, F; Le Gouill, S; Blin, N; Gastinne, T; Mahé, B; Dubruille, V; Moreau, P; Mohty, M

Guillaume, T; Gaugler, B; Chevallier, P; Delaunay, J; Ayari, S; Clavert, A; Rialland, F; Le Gouill, S; Blin, N; Gastinne, T; Mahé, B; Dubruille, V; Moreau, P; Mohty, M.

Affiliation

Guillaume T; Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, 1 Place Ricordeau, Nantes, France. thierry.guillaume@chu-nantes.fr

Bone Marrow Transplant ; 47(8): 1112-7, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22120986

Subject(s)

Graft vs Host Disease/prevention & control; Hematologic Neoplasms/therapy; Hematopoietic Stem Cell Transplantation; Living Donors; Lymphocyte Depletion/methods; Lymphocyte Transfusion/methods; Adolescent; Adult; Aged; Female; Graft vs Host Disease/blood; Graft vs Host Disease/epidemiology; Hematologic Neoplasms/blood; Hematologic Neoplasms/epidemiology; Humans; Incidence; Interleukin-5/blood; Interleukin-7/blood; Male; Middle Aged; Pilot Projects; Prospective Studies; T-Lymphocytes, Regulatory/metabolism; Time Factors; Transplantation, Homologous

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Lymphocyte Depletion / Lymphocyte Transfusion / Hematopoietic Stem Cell Transplantation / Hematologic Neoplasms / Living Donors / Graft vs Host Disease Type of study: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Bone Marrow Transplant Year: 2012 Document type: Article

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