The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism.

van Mastbergen, J; Jolas, T; Allegra, L; Page, C P

van Mastbergen, J; Jolas, T; Allegra, L; Page, C P.

Affiliation

van Mastbergen J; Eurodrug Laboratories, The Hague, The Netherlands.

Pulm Pharmacol Ther ; 25(1): 55-61, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22138191

Subject(s)

Bronchodilator Agents/pharmacology; Histone Deacetylase Inhibitors/pharmacology; Phosphodiesterase Inhibitors/pharmacology; Purinergic P1 Receptor Antagonists/pharmacology; Theophylline/analogs & derivatives; Cell Line; Cell Membrane/drug effects; Cyclic Nucleotide Phosphodiesterases, Type 2/metabolism; Dose-Response Relationship, Drug; Histone Deacetylases/analysis; Histone Deacetylases/metabolism; Humans; Isoenzymes/antagonists & inhibitors; Phosphoric Diester Hydrolases/analysis; Phosphoric Diester Hydrolases/metabolism; Receptor, Adenosine A2A/drug effects; Receptor, Adenosine A2A/metabolism; Regression Analysis; Reproducibility of Results; Theophylline/pharmacology; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Theophylline / Bronchodilator Agents / Histone Deacetylase Inhibitors / Purinergic P1 Receptor Antagonists Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Pulm Pharmacol Ther Year: 2012 Document type: Article

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