The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.

Saxena, H; Deshpande, D A; Tiegs, B C; Yan, H; Battafarano, R J; Burrows, W M; Damera, G; Panettieri, R A; Dubose, T D; An, S S; Penn, R B

Saxena, H; Deshpande, D A; Tiegs, B C; Yan, H; Battafarano, R J; Burrows, W M; Damera, G; Panettieri, R A; Dubose, T D; An, S S; Penn, R B.

Affiliation

Saxena H; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201-1075, USA.

Br J Pharmacol ; 166(3): 981-90, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22145625

Subject(s)

Extracellular Fluid/chemistry; Muscle Contraction/drug effects; Muscle, Smooth/metabolism; Receptors, G-Protein-Coupled/physiology; Signal Transduction/physiology; Bronchi/cytology; Bronchi/drug effects; Cell Culture Techniques; Cells, Cultured; Cyclic AMP/metabolism; Cyclooxygenase Inhibitors/pharmacology; Dose-Response Relationship, Drug; Humans; Hydrochloric Acid/pharmacology; Hydrogen-Ion Concentration; Indomethacin/pharmacology; Muscle, Smooth/cytology; Muscle, Smooth/drug effects; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled/metabolism; Signal Transduction/drug effects; Trachea/cytology; Trachea/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Extracellular Fluid / Receptors, G-Protein-Coupled / Muscle Contraction / Muscle, Smooth Limits: Humans Language: En Journal: Br J Pharmacol Year: 2012 Document type: Article

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