Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling.

O'Connell, Séin; Tuite, Niamh; Slattery, Craig; Ryan, Michael P; McMorrow, Tara

O'Connell, Séin; Tuite, Niamh; Slattery, Craig; Ryan, Michael P; McMorrow, Tara.

Affiliation

O'Connell S; UCD School of Biomolecular and Biomedical Research, UCD Conway Institute, University College Dublin, Dublin 4, Ireland.

Toxicol Sci ; 126(1): 101-13, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22147139

Subject(s)

Cyclosporine/adverse effects; Immunosuppressive Agents/adverse effects; MAP Kinase Signaling System/drug effects; Mesangial Cells/drug effects; Oxidative Stress/drug effects; Renal Insufficiency/chemically induced; Apoptosis/drug effects; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Adhesion/drug effects; Cell Line; Cell Proliferation/drug effects; Computational Biology/methods; Gene Expression Profiling; Gene Expression Regulation/drug effects; Humans; Mesangial Cells/metabolism; Mesangial Cells/pathology; Oligonucleotide Array Sequence Analysis; Osmolar Concentration; Reactive Oxygen Species/metabolism; Renal Insufficiency/metabolism; Renal Insufficiency/pathology; Time Factors; Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Oxidative Stress / MAP Kinase Signaling System / Mesangial Cells / Renal Insufficiency / Immunosuppressive Agents Limits: Humans Language: En Journal: Toxicol Sci Year: 2012 Document type: Article

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