Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.

Lavelle, Donald; Vaitkus, Kestis; Ling, Yonghua; Ruiz, Maria A; Mahfouz, Reda; Ng, Kwok Peng; Negrotto, Soledad; Smith, Nicola; Terse, Pramod; Engelke, Kory J; Covey, Joseph; Chan, Kenneth K; Desimone, Joseph; Saunthararajah, Yogen

Lavelle, Donald; Vaitkus, Kestis; Ling, Yonghua; Ruiz, Maria A; Mahfouz, Reda; Ng, Kwok Peng; Negrotto, Soledad; Smith, Nicola; Terse, Pramod; Engelke, Kory J; Covey, Joseph; Chan, Kenneth K; Desimone, Joseph; Saunthararajah, Yogen.

Affiliation

Lavelle D; Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Blood ; 119(5): 1240-7, 2012 Feb 02.

Article in En | MEDLINE | ID: mdl-22160381

Subject(s)

Azacitidine/analogs & derivatives; Tetrahydrouridine/pharmacology; Administration, Oral; Animals; Antimetabolites/pharmacology; Antimetabolites, Antineoplastic/adverse effects; Antimetabolites, Antineoplastic/metabolism; Antimetabolites, Antineoplastic/pharmacokinetics; Area Under Curve; Azacitidine/administration & dosage; Azacitidine/adverse effects; Azacitidine/metabolism; Azacitidine/pharmacokinetics; Biological Availability; DNA Damage/drug effects; DNA Methylation/drug effects; Decitabine; Drug Interactions; Female; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/metabolism; Inactivation, Metabolic; Injections, Intravenous; Injections, Subcutaneous; Mice; Papio anubis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Tetrahydrouridine Type of study: Evaluation_studies / Prognostic_studies Limits: Animals Language: En Journal: Blood Year: 2012 Document type: Article

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