[PSA bounce after brachytherapy with permanent seed implantation for prostate cancer].
Nihon Hinyokika Gakkai Zasshi
; 102(5): 669-74, 2011 Sep.
Article
in Ja
| MEDLINE
| ID: mdl-22191274
ABSTRACT
PURPOSE:
To evaluate prostate specific antigen (PSA) bounce that may occur as a time PSA rise phenomenon during follow up period after brachytherapy (BT) with permanent seed implantation for prostate cancer. (Materials and methods) Seven hundred and forty-six patients had undergone BT from November 2003 to April 2007 in a single institute, and of 130 patients who did not receive hormone therapy and had minimal 3-year follow up are analyzed. PSA bounce was defined as a rise of at least 0.4 ng/ml with spontaneous return to pre-bounce level or lower.RESULT:
Among the 130 patients, 40 patients (30.8%) developed PSA bounce, and median time to PSA bounce was 18 months after the BT. With univariate analysis, younger patients (P = 0.027) and larger prostate (P = 0.030) had statistically significant correlation with PSA bounce. With multivariate analysis, younger patients were identified as only independent factor for predicting PSA bounce. Eight patients out of 130 patients (6.2%) triggered the Phoenix definition (nadir + 2 ng/ml) of PSA failure, however, clinical failure was seen only in 3 patients, and other 5 patients were considered as PSA bounce.CONCLUSION:
PSA bounce is likely to occur in younger patients within 3 years after BT. It is clinically important to distinguish PSA bounce from PSA failure during following period after BT.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Brachytherapy
/
Prostate-Specific Antigen
Type of study:
Prognostic_studies
Limits:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
Ja
Journal:
Nihon Hinyokika Gakkai Zasshi
Year:
2011
Document type:
Article