High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome.

Duijkers, Floor A M; Gaal, José; Meijerink, Jules P P; Admiraal, Pieter; Pieters, Rob; de Krijger, Ronald R; van Noesel, Max M

Duijkers, Floor A M; Gaal, José; Meijerink, Jules P P; Admiraal, Pieter; Pieters, Rob; de Krijger, Ronald R; van Noesel, Max M.

Affiliation

Duijkers FAM; Department of Pediatric Oncology-Hematology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands.
Gaal J; Department of Pathology, University Medical Center, Erasmus MC, Rotterdam, the Netherlands.
Meijerink JPP; Department of Pediatric Oncology-Hematology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands.
Admiraal P; Department of Pediatric Oncology-Hematology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands.
Pieters R; Department of Pediatric Oncology-Hematology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands.
de Krijger RR; Department of Pathology, University Medical Center, Erasmus MC, Rotterdam, the Netherlands.
van Noesel MM; Department of Pediatric Oncology-Hematology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands. Electronic address: m.vannoesel@erasmusmc.nl.

Am J Pathol ; 180(3): 1223-1231, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22203052

Subject(s)

Ganglioneuroblastoma/metabolism; Neuroblastoma/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Anaplastic Lymphoma Kinase; Child; Child, Preschool; Female; Ganglioneuroblastoma/mortality; Humans; Immunohistochemistry; Male; N-Myc Proto-Oncogene Protein; Neuroblastoma/mortality; Nuclear Proteins/genetics; Oncogene Proteins/genetics; Point Mutation/genetics; Prognosis; Receptor Protein-Tyrosine Kinases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor Protein-Tyrosine Kinases / Ganglioneuroblastoma / Neuroblastoma Type of study: Prognostic_studies / Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Male Language: En Journal: Am J Pathol Year: 2012 Document type: Article

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