Infiltrating cellular pattern in kidney graft biopsies translates into forkhead box protein 3 up-regulation and p16INK4&#945; senescence protein down-regulation in patients treated with belatacept compared to cyclosporin A.

Furuzawa-Carballeda, J; Lima, G; Alberú, J; Palafox, D; Uribe-Uribe, N; Morales-Buenrostro, L E; Reyes Acevedo, R; Mondragón, G; Chevaile, A; Llorente, L

Infiltrating cellular pattern in kidney graft biopsies translates into forkhead box protein 3 up-regulation and p16INK4α senescence protein down-regulation in patients treated with belatacept compared to cyclosporin A.

Furuzawa-Carballeda, J; Lima, G; Alberú, J; Palafox, D; Uribe-Uribe, N; Morales-Buenrostro, L E; Reyes Acevedo, R; Mondragón, G; Chevaile, A; Llorente, L.

Affiliation

Furuzawa-Carballeda J; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.

Clin Exp Immunol ; 167(2): 330-7, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22236010

Subject(s)

Cellular Senescence/drug effects; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis; Cyclosporine/pharmacology; Down-Regulation/drug effects; Forkhead Transcription Factors/biosynthesis; Immunoconjugates/pharmacology; Immunosuppressive Agents/pharmacology; Kidney Transplantation; Kidney/pathology; Nephritis, Interstitial/chemically induced; Abatacept; Adrenal Cortex Hormones/therapeutic use; Adult; Antibodies, Monoclonal/therapeutic use; Basiliximab; Clinical Trials, Phase III as Topic/statistics & numerical data; Cyclosporine/therapeutic use; Double-Blind Method; Female; Forkhead Transcription Factors/genetics; Genes, p16; Humans; Immunoconjugates/therapeutic use; Immunosuppressive Agents/therapeutic use; Kidney/drug effects; Kidney/metabolism; Male; Middle Aged; Multicenter Studies as Topic/statistics & numerical data; Mycophenolic Acid/analogs & derivatives; Mycophenolic Acid/therapeutic use; Nephritis, Interstitial/immunology; Nephritis, Interstitial/metabolism; Nephritis, Interstitial/pathology; Randomized Controlled Trials as Topic/statistics & numerical data; Recombinant Fusion Proteins/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down-Regulation / Kidney Transplantation / Cyclosporine / Cellular Senescence / Immunoconjugates / Cyclin-Dependent Kinase Inhibitor p16 / Forkhead Transcription Factors / Immunosuppressive Agents / Kidney / Nephritis, Interstitial Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Exp Immunol Year: 2012 Document type: Article

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