ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.

Lee, J; Hong, Y K; Jeon, G S; Hwang, Y J; Kim, K Y; Seong, K H; Jung, M-K; Picketts, D J; Kowall, N W; Cho, K S; Ryu, H

Lee, J; Hong, Y K; Jeon, G S; Hwang, Y J; Kim, K Y; Seong, K H; Jung, M-K; Picketts, D J; Kowall, N W; Cho, K S; Ryu, H.

Affiliation

Lee J; VA Boston Healthcare System, MA, USA.

Cell Death Differ ; 19(7): 1109-16, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22240898

Subject(s)

DNA Helicases/metabolism; Heterochromatin/metabolism; Homeodomain Proteins/metabolism; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Animals; Base Sequence; CDX2 Transcription Factor; Cell Line; DNA Helicases/antagonists & inhibitors; DNA Helicases/genetics; Drosophila; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Histones/metabolism; Humans; Huntingtin Protein; Huntington Disease/metabolism; Huntington Disease/pathology; Male; Methylation; Mice; Molecular Sequence Data; Mutation; Nerve Tissue Proteins/genetics; Nuclear Proteins/antagonists & inhibitors; Nuclear Proteins/genetics; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering/metabolism; X-linked Nuclear Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Heterochromatin / DNA Helicases / Homeodomain Proteins / Nerve Tissue Proteins Limits: Animals / Humans / Male Language: En Journal: Cell Death Differ Year: 2012 Document type: Article

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