A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice.

Mishiro, K; Ishiguro, M; Suzuki, Y; Tsuruma, K; Shimazawa, M; Hara, H

Mishiro, K; Ishiguro, M; Suzuki, Y; Tsuruma, K; Shimazawa, M; Hara, H.

Affiliation

Mishiro K; Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan.

Neuroscience ; 205: 39-48, 2012 Mar 15.

Article in En | MEDLINE | ID: mdl-22244977

Subject(s)

Cerebral Hemorrhage/chemically induced; Cerebral Hemorrhage/prevention & control; Dipeptides/pharmacology; Fibrinolytic Agents/toxicity; Matrix Metalloproteinase 3/metabolism; Matrix Metalloproteinase Inhibitors/pharmacology; Tissue Plasminogen Activator/antagonists & inhibitors; Tissue Plasminogen Activator/toxicity; Animals; Animals, Outbred Strains; Cerebral Hemorrhage/enzymology; Dipeptides/therapeutic use; Disease Models, Animal; Male; Matrix Metalloproteinase Inhibitors/therapeutic use; Mice

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Hemorrhage / Tissue Plasminogen Activator / Matrix Metalloproteinase 3 / Dipeptides / Fibrinolytic Agents / Matrix Metalloproteinase Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2012 Document type: Article

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