Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
Bioorg Med Chem Lett
; 22(7): 2629-34, 2012 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-22366653
ABSTRACT
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Quinolines
/
Carboxylic Acids
/
Serine Proteinase Inhibitors
/
Viral Nonstructural Proteins
/
Hepacivirus
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Year:
2012
Document type:
Article