Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

Schödel, Johannes; Bardella, Chiara; Sciesielski, Lina K; Brown, Jill M; Pugh, Chris W; Buckle, Veronica; Tomlinson, Ian P; Ratcliffe, Peter J; Mole, David R

Schödel, Johannes; Bardella, Chiara; Sciesielski, Lina K; Brown, Jill M; Pugh, Chris W; Buckle, Veronica; Tomlinson, Ian P; Ratcliffe, Peter J; Mole, David R.

Affiliation

Schödel J; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK. schoedel@well.ox.ac.uk

Nat Genet ; 44(4): 420-5, S1-2, 2012 Mar 11.

Article in En | MEDLINE | ID: mdl-22406644

Subject(s)

Cyclin D1/genetics; Enhancer Elements, Genetic; Genetic Variation; Hypoxia-Inducible Factor 1/metabolism; Kidney Neoplasms/genetics; Cell Cycle Checkpoints/genetics; Cell Hypoxia; Cell Line, Tumor; Chromosomes, Human, Pair 11/genetics; Cyclin D1/biosynthesis; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Kidney Neoplasms/metabolism; Molecular Sequence Data; Polymorphism, Single Nucleotide; Von Hippel-Lindau Tumor Suppressor Protein/genetics; Von Hippel-Lindau Tumor Suppressor Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Enhancer Elements, Genetic / Cyclin D1 / Hypoxia-Inducible Factor 1 / Kidney Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Genet Year: 2012 Document type: Article

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