Analysis of genetic polymorphism of the HLA-B and HLA-DR loci in patients with dermatophytic onychomycosis and in their first-degree relatives.
Actas Dermosifiliogr
; 103(1): 59-62, 2012 Jan.
Article
in En
| MEDLINE
| ID: mdl-22456594
ABSTRACT
Onychomycosis is known to have predisposing factors and a high prevalence within families that cannot be explained by within-family transmission. We determined the frequency of HLA-B and HLA-DR haplotypes in 25 families of Mexican patients with onychomycosis in order to define the role of the class II major histocompatibility complex (MHC) in genetic susceptibility to this infection. Seventy-eight subjects participated in the study, 47 with onychomycosis and 31 healthy individuals. The frequencies of the HLA-B and HLA-DR haplotypes were compared with those found in first-degree relatives without onychomycosis and in a historic control group of healthy individuals. The frequencies in the controls were similar to those of the healthy relatives of the patients. However, on comparison of the patients with historic controls, we detected a higher frequency of the HLA-DR8 haplotype (P=.03; odds ratio, 1.89; 95% confidence interval, 0.98-36). These findings suggest that there are polymorphisms in genes of the MHC that increase susceptibility to onychomycosis, particularly haplotype HLA-DR8.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Tinea Capitis
/
Genes, MHC Class I
/
HLA-B Antigens
/
HLA-DR Antigens
/
Genes, MHC Class II
/
Onychomycosis
/
Foot Dermatoses
/
Hand Dermatoses
Type of study:
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Mexico
Language:
En
Journal:
Actas Dermosifiliogr
Year:
2012
Document type:
Article