Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.

Oliveras-Ferraros, C; Cufí, S; Queralt, B; Vazquez-Martin, A; Martin-Castillo, B; de Llorens, R; Bosch-Barrera, J; Brunet, J; Menendez, J A

Oliveras-Ferraros, C; Cufí, S; Queralt, B; Vazquez-Martin, A; Martin-Castillo, B; de Llorens, R; Bosch-Barrera, J; Brunet, J; Menendez, J A.

Affiliation

Oliveras-Ferraros C; Unit of Translational Research, Catalan Institute of Oncology, Girona, Spain.

Br J Cancer ; 106(8): 1406-14, 2012 Apr 10.

Article in En | MEDLINE | ID: mdl-22491422

Subject(s)

Antibodies, Monoclonal/pharmacology; Drug Resistance, Neoplasm/drug effects; Epidermal Growth Factor/antagonists & inhibitors; ErbB Receptors/metabolism; Glycoproteins/antagonists & inhibitors; Receptor, Fibroblast Growth Factor, Type 3/metabolism; Signal Transduction/drug effects; Skin Neoplasms/pathology; Amphiregulin; Antibodies, Monoclonal, Humanized; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Cell Survival/drug effects; Cetuximab; EGF Family of Proteins; Epidermal Growth Factor/biosynthesis; Epidermal Growth Factor/genetics; Epiregulin; Gene Knockdown Techniques; Glycoproteins/biosynthesis; Glycoproteins/genetics; Humans; Intercellular Signaling Peptides and Proteins/biosynthesis; Intercellular Signaling Peptides and Proteins/genetics; Ligands; Pyrimidines/pharmacology; Skin Neoplasms/drug therapy; Structure-Activity Relationship; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Skin Neoplasms / Glycoproteins / Signal Transduction / Drug Resistance, Neoplasm / Epidermal Growth Factor / Receptor, Fibroblast Growth Factor, Type 3 / ErbB Receptors / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Br J Cancer Year: 2012 Document type: Article

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