Anti-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells.
Am J Transplant
; 12(8): 2072-8, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22494812
ABSTRACT
The role of B cells in transplant tolerance remains unclear. Although B-cell depletion often prolongs graft survival, sometimes it results in more rapid rejection, suggesting that B cells may have regulatory activity. We previously demonstrated that tolerance induction by anti-CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all recipients in a mouse islet allograft model. This effect depends on the presence of recipient B cells, requires B-cell IL-10 activity, and is antigen-specific. These data suggest the existence of a regulatory B-cell population that promotes tolerance via an IL-10-dependent pathway.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
/
Leukocyte Common Antigens
/
Immune Tolerance
/
Membrane Proteins
Limits:
Animals
Language:
En
Journal:
Am J Transplant
Year:
2012
Document type:
Article