Reduction of renal uptake of radiolabeled octreotate by amifostine coadministration.

Melis, Marleen; Valkema, Roelf; Krenning, Eric P; de Jong, Marion

Melis, Marleen; Valkema, Roelf; Krenning, Eric P; de Jong, Marion.

Affiliation

Melis M; Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. m.melis@erasmusmc.nl

J Nucl Med ; 53(5): 749-53, 2012 May.

Article in En | MEDLINE | ID: mdl-22496587

Subject(s)

Amifostine/administration & dosage; Amifostine/pharmacology; Coordination Complexes/administration & dosage; Coordination Complexes/metabolism; Kidney/drug effects; Kidney/metabolism; Octreotide/analogs & derivatives; Organometallic Compounds/administration & dosage; Organometallic Compounds/metabolism; Animals; Biological Transport/drug effects; Cell Line, Tumor; Coordination Complexes/pharmacokinetics; Gene Expression Regulation, Neoplastic; Isotope Labeling; Male; Octreotide/administration & dosage; Octreotide/metabolism; Octreotide/pharmacokinetics; Organometallic Compounds/pharmacokinetics; Radiation-Protective Agents/administration & dosage; Radiation-Protective Agents/pharmacology; Rats; Receptors, Somatostatin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Octreotide / Amifostine / Coordination Complexes / Kidney Limits: Animals Language: En Journal: J Nucl Med Year: 2012 Document type: Article

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