A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

Torikai, Hiroki; Reik, Andreas; Liu, Pei-Qi; Zhou, Yuanyue; Zhang, Ling; Maiti, Sourindra; Huls, Helen; Miller, Jeffrey C; Kebriaei, Partow; Rabinovich, Brian; Rabinovitch, Brian; Lee, Dean A; Champlin, Richard E; Bonini, Chiara; Naldini, Luigi; Rebar, Edward J; Gregory, Philip D; Holmes, Michael C; Cooper, Laurence J N

Torikai, Hiroki; Reik, Andreas; Liu, Pei-Qi; Zhou, Yuanyue; Zhang, Ling; Maiti, Sourindra; Huls, Helen; Miller, Jeffrey C; Kebriaei, Partow; Rabinovich, Brian; Rabinovitch, Brian; Lee, Dean A; Champlin, Richard E; Bonini, Chiara; Naldini, Luigi; Rebar, Edward J; Gregory, Philip D; Holmes, Michael C; Cooper, Laurence J N.

Affiliation

Torikai H; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Blood ; 119(24): 5697-705, 2012 Jun 14.

Article in En | MEDLINE | ID: mdl-22535661

Subject(s)

Antigens, CD19/immunology; Epitopes/immunology; Genetic Engineering; Immunotherapy/methods; Receptors, Antigen, T-Cell/immunology; Recombinant Proteins/immunology; T-Lymphocytes/immunology; Adult; Antigen-Presenting Cells/immunology; Antigens, Neoplasm/immunology; CD28 Antigens/metabolism; CD3 Complex/metabolism; Cells, Cultured; Endonucleases/metabolism; Gene Knockout Techniques; Humans; K562 Cells; Lymphocyte Activation/immunology; Zinc Fingers

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Receptors, Antigen, T-Cell / T-Lymphocytes / Genetic Engineering / Antigens, CD19 / Immunotherapy / Epitopes Limits: Adult / Humans Language: En Journal: Blood Year: 2012 Document type: Article

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