Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior.

Vigers, A J; Amin, D S; Talley-Farnham, T; Gorski, J A; Xu, B; Jones, K R

Vigers, A J; Amin, D S; Talley-Farnham, T; Gorski, J A; Xu, B; Jones, K R.

Affiliation

Vigers AJ; Department of Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309, USA. vigers@colorado.edu

Neuroscience ; 212: 1-18, 2012 Jun 14.

Article in En | MEDLINE | ID: mdl-22542678

Subject(s)

Brain-Derived Neurotrophic Factor/biosynthesis; Cerebral Cortex/growth & development; Cerebral Cortex/metabolism; Dendritic Spines/metabolism; Developmental Disabilities/metabolism; Mental Disorders/metabolism; Animals; Behavior, Animal/physiology; Brain-Derived Neurotrophic Factor/deficiency; Brain-Derived Neurotrophic Factor/genetics; Dendritic Spines/pathology; Developmental Disabilities/genetics; Developmental Disabilities/physiopathology; Disease Models, Animal; Female; Male; Mental Disorders/genetics; Mental Disorders/physiopathology; Mice; Mice, Knockout; Mice, Transgenic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Cortex / Developmental Disabilities / Brain-Derived Neurotrophic Factor / Dendritic Spines / Mental Disorders Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2012 Document type: Article

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