Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-&#954;B activation, and colonic fibrosis.

Guo, Lei; Ye, Caiying; Hao, Xiaojian; Zheng, Ru; Ju, Rui; Wu, Danwei; Luo, Lifeng; Wang, Conghui; Li, Juan; Yu, Xiaoli; Zhu, Lei; Zhang, Dechang

Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-κB activation, and colonic fibrosis.

Guo, Lei; Ye, Caiying; Hao, Xiaojian; Zheng, Ru; Ju, Rui; Wu, Danwei; Luo, Lifeng; Wang, Conghui; Li, Juan; Yu, Xiaoli; Zhu, Lei; Zhang, Dechang.

Affiliation

Guo L; Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.

J Pharmacol Exp Ther ; 342(2): 356-65, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22553216

Subject(s)

Colitis/drug therapy; Colon/drug effects; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Triazoles/pharmacology; Animals; Colitis/blood; Colitis/metabolism; Colitis/pathology; Colon/metabolism; Colon/pathology; Dextran Sulfate; Fibrosis; Inflammation/blood; Inflammation/drug therapy; Inflammation/metabolism; Inflammation/pathology; Inflammatory Bowel Diseases/blood; Inflammatory Bowel Diseases/drug therapy; Inflammatory Bowel Diseases/metabolism; Inflammatory Bowel Diseases/pathology; Intercellular Adhesion Molecule-1/metabolism; Interleukin-1beta/blood; Interleukin-1beta/metabolism; Interleukin-6/blood; Interleukin-6/metabolism; Macrophages, Peritoneal/drug effects; Macrophages, Peritoneal/metabolism; Macrophages, Peritoneal/pathology; Male; Mice; Mice, Inbred C57BL; Mucous Membrane/drug effects; Mucous Membrane/metabolism; Mucous Membrane/pathology; Phosphorylation/drug effects; Proteolysis/drug effects; Tumor Necrosis Factor-alpha/blood; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / NF-kappa B / Colitis / Colon Language: En Journal: J Pharmacol Exp Ther Year: 2012 Document type: Article

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