Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice.

Kulandavelu, Shathiyah; Whiteley, Kathie J; Qu, Dawei; Mu, Junwu; Bainbridge, Shannon A; Adamson, S Lee

Kulandavelu, Shathiyah; Whiteley, Kathie J; Qu, Dawei; Mu, Junwu; Bainbridge, Shannon A; Adamson, S Lee.

Affiliation

Kulandavelu S; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Hypertension ; 60(1): 231-8, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22615111

Subject(s)

Nitric Oxide Synthase Type III/deficiency; Placenta/metabolism; Uterine Artery/physiology; Uterus/metabolism; Animals; Blood Flow Velocity; Enzyme-Linked Immunosorbent Assay; Female; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Immunohistochemistry; Killer Cells, Natural/immunology; Killer Cells, Natural/metabolism; Lymphocyte Count; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Scanning; Nitric Oxide Synthase Type III/genetics; Oxygen/metabolism; Placenta/blood supply; Placenta/immunology; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Necrosis Factor-alpha/blood; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; Uterine Artery/ultrastructure; Uterus/blood supply; Vascular Endothelial Growth Factor Receptor-1/blood; Vascular Endothelial Growth Factor Receptor-1/genetics; Vascular Endothelial Growth Factor Receptor-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placenta / Uterus / Nitric Oxide Synthase Type III / Uterine Artery Limits: Animals / Pregnancy Language: En Journal: Hypertension Year: 2012 Document type: Article

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