Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G9³A) mice.

Staats, K A; Van Rillaer, M; Scheveneels, W; Verbesselt, R; Van Damme, P; Robberecht, W; Van Den Bosch, L

Staats, K A; Van Rillaer, M; Scheveneels, W; Verbesselt, R; Van Damme, P; Robberecht, W; Van Den Bosch, L.

Affiliation

Staats KA; Laboratory of Neurobiology and Leuven research Institute for Neurodegenerative Disorders (LIND), KU Leuven, Belgium.

Neuroscience ; 220: 26-31, 2012 Sep 18.

Article in En | MEDLINE | ID: mdl-22750242

Subject(s)

Amyotrophic Lateral Sclerosis/metabolism; Dantrolene/pharmacology; Motor Neurons/drug effects; Neuroprotective Agents/pharmacology; Ryanodine Receptor Calcium Release Channel/metabolism; Animals; Calcium/metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase/genetics; Superoxide Dismutase-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuroprotective Agents / Ryanodine Receptor Calcium Release Channel / Dantrolene / Amyotrophic Lateral Sclerosis / Motor Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Neuroscience Year: 2012 Document type: Article

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