IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

Sasaki, Masato; Knobbe, Christiane B; Munger, Joshua C; Lind, Evan F; Brenner, Dirk; Brüstle, Anne; Harris, Isaac S; Holmes, Roxanne; Wakeham, Andrew; Haight, Jillian; You-Ten, Annick; Li, Wanda Y; Schalm, Stefanie; Su, Shinsan M; Virtanen, Carl; Reifenberger, Guido; Ohashi, Pamela S; Barber, Dwayne L; Figueroa, Maria E; Melnick, Ari; Zúñiga-Pflücker, Juan-Carlos; Mak, Tak W

Sasaki, Masato; Knobbe, Christiane B; Munger, Joshua C; Lind, Evan F; Brenner, Dirk; Brüstle, Anne; Harris, Isaac S; Holmes, Roxanne; Wakeham, Andrew; Haight, Jillian; You-Ten, Annick; Li, Wanda Y; Schalm, Stefanie; Su, Shinsan M; Virtanen, Carl; Reifenberger, Guido; Ohashi, Pamela S; Barber, Dwayne L; Figueroa, Maria E; Melnick, Ari; Zúñiga-Pflücker, Juan-Carlos; Mak, Tak W.

Affiliation

Sasaki M; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada.

Nature ; 488(7413): 656-9, 2012 Aug 30.

Article in En | MEDLINE | ID: mdl-22763442

Subject(s)

Epigenesis, Genetic/genetics; Hematopoietic Stem Cells/cytology; Isocitrate Dehydrogenase/genetics; Isocitrate Dehydrogenase/metabolism; Mutant Proteins/metabolism; Mutation/genetics; Aging; Animals; Bone Marrow/pathology; Cell Lineage; CpG Islands/genetics; DNA Methylation; Disease Models, Animal; Female; Gene Knock-In Techniques; Glioma/pathology; Hematopoiesis; Hematopoietic Stem Cells/metabolism; Histones/metabolism; Humans; Leukemia, Myeloid, Acute/genetics; Male; Mice; Mutant Proteins/genetics; Myeloid Cells/cytology; Myeloid Cells/metabolism; Spleen/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Epigenesis, Genetic / Mutant Proteins / Isocitrate Dehydrogenase / Mutation Limits: Animals / Female / Humans / Male Language: En Journal: Nature Year: 2012 Document type: Article

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