Sulfated hyaluronan/collagen I matrices enhance the osteogenic differentiation of human mesenchymal stromal cells in vitro even in the absence of dexamethasone.

Hempel, U; Möller, S; Noack, C; Hintze, V; Scharnweber, D; Schnabelrauch, M; Dieter, P

Hempel, U; Möller, S; Noack, C; Hintze, V; Scharnweber, D; Schnabelrauch, M; Dieter, P.

Affiliation

Hempel U; Institute of Physiological Chemistry, Carl Gustav Carus, Faculty of Medicine, Technische Universität Dresden, Fiedlerstrasse 42, D-01307 Dresden, Germany. ute.hempel@tu-dresden.de

Acta Biomater ; 8(11): 4064-72, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22771456

Subject(s)

Cell Differentiation/drug effects; Collagen Type I/pharmacology; Dexamethasone/pharmacology; Hyaluronic Acid/pharmacology; Mesenchymal Stem Cells/cytology; Sulfates/pharmacology; Adult; Alkaline Phosphatase/genetics; Alkaline Phosphatase/metabolism; Animals; Calcium Phosphates/metabolism; Core Binding Factor Alpha 1 Subunit/genetics; Core Binding Factor Alpha 1 Subunit/metabolism; Extracellular Matrix/drug effects; Extracellular Matrix/metabolism; Gene Expression Regulation/drug effects; Glycosaminoglycans/chemistry; Glycosaminoglycans/metabolism; Humans; Hyaluronic Acid/chemical synthesis; Hyaluronic Acid/chemistry; Integrin-Binding Sialoprotein/genetics; Integrin-Binding Sialoprotein/metabolism; Male; Mesenchymal Stem Cells/drug effects; Mesenchymal Stem Cells/enzymology; Osteocalcin/genetics; Osteocalcin/metabolism; Osteogenesis/drug effects; Rats; Staining and Labeling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfates / Dexamethasone / Cell Differentiation / Collagen Type I / Mesenchymal Stem Cells / Hyaluronic Acid Limits: Adult / Animals / Humans / Male Language: En Journal: Acta Biomater Year: 2012 Document type: Article

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