In vivo rat PK profiling in drug discovery: new challenges.

Zonzini, Laura; Bianchi, Federica; Cesari, Nicola; Sartori, Matteo

Zonzini, Laura; Bianchi, Federica; Cesari, Nicola; Sartori, Matteo.

Affiliation

Zonzini L; GlaxoSmithKline SpA, Neurosciences Centre of Excellence for Drug Discovery, Medicine Research Centre, Verona, Italy.

Expert Opin Drug Discov ; 5(11): 1031-7, 2010 Nov.

Article in En | MEDLINE | ID: mdl-22827743

Subject(s)

Drug Discovery/methods; Pharmaceutical Preparations/metabolism; Pharmacokinetics; Rats/metabolism; Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Injections, Intravenous; Pharmaceutical Preparations/administration & dosage; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rats / Pharmacokinetics / Pharmaceutical Preparations / Drug Discovery Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Expert Opin Drug Discov Year: 2010 Document type: Article

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