Contrast enhanced MRI and ¹8F-FDG PET-CT in the assessment of multiple myeloma: a comparison of results in different phases of the disease.
Eur J Radiol
; 81(12): 4013-8, 2012 Dec.
Article
in En
| MEDLINE
| ID: mdl-22921683
ABSTRACT
OBJECTIVES:
The aim of our study was to compare the accuracy of contrast enhanced MRI and FDG PET-CT in the staging, treatment evaluation and follow-up of multiple myeloma.METHODS:
We retrospectively reviewed 210 PET-CT and 210 MRI studies of patients affected by multiple myeloma. MRI was always performed within 15 days of PET-CT. All the images have been evaluated by two expert oncologic radiologists.RESULTS:
Patient population included 81 females and 110 males (age 61.9 ± 9.9 years-old). Sixty-two patients have been evaluated at diagnosis, 58 at the end of therapies and 90 during follow-up. In 12/62 patients (19.4%) at diagnosis, differences between MRI and PET-CT findings determined changes in the staging PET-CT was responsible for 11 down-staging (17.7%) and MRI only for one (1.6%). In 27/40 patients (67.5%) with good or complete clinical response to therapies the normalization of findings was faster for PET-CT than MRI. Ten out of 90 patients (10/90 - 11.1%) in follow-up protocol presented clinical recurrence of the disease MRI detected active lesions in 8 of them (80.0%) and PET-CT in 5 patients (50.0%, all detected by MRI too).CONCLUSIONS:
MRI achieved better results than PET-CT in the staging and in patients with multiple myeloma recurrence. PET-CT, showed prompt change of imaging findings, faster than MRI, in patients with positive response to therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Tomography, X-Ray Computed
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
/
Multimodal Imaging
/
Gadolinium
/
Multiple Myeloma
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur J Radiol
Year:
2012
Document type:
Article