PLGA microspheres encapsulating siRNA anti-TNFalpha: efficient RNAi-mediated treatment of arthritic joints.

Présumey, J; Salzano, G; Courties, G; Shires, M; Ponchel, F; Jorgensen, C; Apparailly, F; De Rosa, G

Présumey, J; Salzano, G; Courties, G; Shires, M; Ponchel, F; Jorgensen, C; Apparailly, F; De Rosa, G.

Affiliation

Présumey J; Inserm, U 844, INM, Hôpital Saint Eloi, Montpellier, France.

Eur J Pharm Biopharm ; 82(3): 457-64, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22922428

Subject(s)

Arthritis, Experimental/pathology; Arthritis, Rheumatoid/pathology; RNA, Small Interfering/administration & dosage; Tumor Necrosis Factor-alpha/genetics; Animals; Arthritis, Experimental/therapy; Arthritis, Rheumatoid/therapy; Cell Line; Drug Design; Lactic Acid/chemistry; Mice; Mice, Inbred DBA; Microspheres; Particle Size; Polyglycolic Acid/chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; RNA Interference; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Arthritis, Rheumatoid / Tumor Necrosis Factor-alpha / RNA, Small Interfering Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Biopharm Year: 2012 Document type: Article

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