Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel.
Clin Microbiol Infect
; 19(8): 752-6, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23005038
ABSTRACT
The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candida
/
Fluconazole
/
Cross Infection
/
Drug Resistance, Fungal
/
Candidemia
/
Antifungal Agents
Type of study:
Observational_studies
/
Prevalence_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Clin Microbiol Infect
Year:
2013
Document type:
Article