Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of &#945;2A-adrenoceptor.

Nakagawa, T; Nagayasu, K; Nishitani, N; Shirakawa, H; Sekiguchi, K; Ikarashi, Y; Kase, Y; Kaneko, S

Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α2A-adrenoceptor.

Nakagawa, T; Nagayasu, K; Nishitani, N; Shirakawa, H; Sekiguchi, K; Ikarashi, Y; Kase, Y; Kaneko, S.

Affiliation

Nakagawa T; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. tnakaga@pharm.kyoto-u.ac.jp

Neuroscience ; 227: 336-49, 2012 Dec 27.

Article in En | MEDLINE | ID: mdl-23069764

Subject(s)

Behavior, Addictive/drug therapy; Drugs, Chinese Herbal/therapeutic use; Morphine Dependence/drug therapy; Receptors, Adrenergic, alpha-2/metabolism; Adrenergic Agents/pharmacology; Adrenergic alpha-Antagonists/pharmacokinetics; Adrenergic beta-Antagonists/pharmacology; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacokinetics; Guanosine Diphosphate/pharmacology; Isotopes/pharmacokinetics; Male; Mice; Norepinephrine Plasma Membrane Transport Proteins/metabolism; Pain Threshold/drug effects; Propranolol/pharmacology; Protein Binding/drug effects; Radioligand Assay; Time Factors; Tropanes/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Behavior, Addictive / Receptors, Adrenergic, alpha-2 / Morphine Dependence Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2012 Document type: Article

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