Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation.

Ding, Wen-Xing; Guo, Fengli; Ni, Hong-Min; Bockus, Abigail; Manley, Sharon; Stolz, Donna B; Eskelinen, Eeva-Liisa; Jaeschke, Hartmut; Yin, Xiao-Ming

Ding, Wen-Xing; Guo, Fengli; Ni, Hong-Min; Bockus, Abigail; Manley, Sharon; Stolz, Donna B; Eskelinen, Eeva-Liisa; Jaeschke, Hartmut; Yin, Xiao-Ming.

Affiliation

Ding WX; Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA. wxding@kumc.edu

J Biol Chem ; 287(50): 42379-88, 2012 Dec 07.

Article in En | MEDLINE | ID: mdl-23095748

Subject(s)

GTP Phosphohydrolases/metabolism; Mitochondria, Liver/metabolism; Mitochondrial Dynamics/physiology; Mitophagy/physiology; Ubiquitin-Protein Ligases/metabolism; Acetaminophen/adverse effects; Acetaminophen/pharmacology; Analgesics, Non-Narcotic/adverse effects; Analgesics, Non-Narcotic/pharmacology; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology; Cells, Cultured; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/pathology; GTP Phosphohydrolases/genetics; Liver/metabolism; Liver/ultrastructure; Mice; Mice, Knockout; Mitochondria, Liver/ultrastructure; Mitochondrial Dynamics/drug effects; Mitophagy/drug effects; Proteolysis/drug effects; Proton Ionophores/pharmacology; Reactive Oxygen Species/metabolism; Ubiquitin-Protein Ligases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Ubiquitin-Protein Ligases / Mitophagy / Mitochondrial Dynamics / GTP Phosphohydrolases Limits: Animals Language: En Journal: J Biol Chem Year: 2012 Document type: Article

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