Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters.

Chun, So Young; Mack, David L; Moorefield, Emily; Oh, Se Heang; Kwon, Tae Gyun; Pettenati, Mark J; Yoo, James J; Coppi, Paolo De; Atala, Anthony; Soker, Shay

Chun, So Young; Mack, David L; Moorefield, Emily; Oh, Se Heang; Kwon, Tae Gyun; Pettenati, Mark J; Yoo, James J; Coppi, Paolo De; Atala, Anthony; Soker, Shay.

Affiliation

Chun SY; Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Daegu, Korea.

J Tissue Eng Regen Med ; 9(5): 540-9, 2015 May.

Article in En | MEDLINE | ID: mdl-23147868

Subject(s)

Cell Culture Techniques/methods; Homeodomain Proteins/metabolism; Insulin/metabolism; Stem Cells/cytology; Trans-Activators/metabolism; Adenoviridae/metabolism; Amniotic Fluid; Animals; C-Peptide/metabolism; Cell Differentiation; Cell- and Tissue-Based Therapy/methods; Culture Media; Culture Media, Serum-Free/chemistry; Diabetes Mellitus/therapy; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix/metabolism; Humans; Insulin-Secreting Cells/cytology; Mice

Key words

Pdx1; amniotic fluid-derived stem cells; cell therapy; diabetes; differentiation; extracellular matrix components; growth factors

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Stem Cells / Trans-Activators / Homeodomain Proteins / Cell Culture Techniques / Insulin Limits: Animals / Humans Language: En Journal: J Tissue Eng Regen Med Year: 2015 Document type: Article

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