An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Gruber, Tanja A; Larson Gedman, Amanda; Zhang, Jinghui; Koss, Cary S; Marada, Suresh; Ta, Huy Q; Chen, Shann-Ching; Su, Xiaoping; Ogden, Stacey K; Dang, Jinjun; Wu, Gang; Gupta, Vedant; Andersson, Anna K; Pounds, Stanley; Shi, Lei; Easton, John; Barbato, Michael I; Mulder, Heather L; Manne, Jayanthi; Wang, Jianmin; Rusch, Michael; Ranade, Swati; Ganti, Ramapriya; Parker, Matthew; Ma, Jing; Radtke, Ina; Ding, Li; Cazzaniga, Giovanni; Biondi, Andrea; Kornblau, Steven M; Ravandi, Farhad; Kantarjian, Hagop; Nimer, Stephen D; Döhner, Konstanze; Döhner, Hartmut; Ley, Timothy J; Ballerini, Paola; Shurtleff, Sheila; Tomizawa, Daisuke; Adachi, Souichi; Hayashi, Yasuhide; Tawa, Akio; Shih, Lee-Yung; Liang, Der-Cherng; Rubnitz, Jeffrey E; Pui, Ching-Hon; Mardis, Elaine R; Wilson, Richard K; Downing, James R

Gruber, Tanja A; Larson Gedman, Amanda; Zhang, Jinghui; Koss, Cary S; Marada, Suresh; Ta, Huy Q; Chen, Shann-Ching; Su, Xiaoping; Ogden, Stacey K; Dang, Jinjun; Wu, Gang; Gupta, Vedant; Andersson, Anna K; Pounds, Stanley; Shi, Lei; Easton, John; Barbato, Michael I; Mulder, Heather L; Manne, Jayanthi; Wang, Jianmin; Rusch, Michael; Ranade, Swati; Ganti, Ramapriya; Parker, Matthew; Ma, Jing; Radtke, Ina; Ding, Li; Cazzaniga, Giovanni; Biondi, Andrea; Kornblau, Steven M; Ravandi, Farhad; Kantarjian, Hagop; Nimer, Stephen D; Döhner, Konstanze; Döhner, Hartmut; Ley, Timothy J; Ballerini, Paola; Shurtleff, Sheila; Tomizawa, Daisuke; Adachi, Souichi; Hayashi, Yasuhide; Tawa, Akio; Shih, Lee-Yung; Liang, Der-Cherng; Rubnitz, Jeffrey E; Pui, Ching-Hon; Mardis, Elaine R; Wilson, Richard K; Downing, James R.

Affiliation

Gruber TA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cancer Cell ; 22(5): 683-97, 2012 Nov 13.

Article in En | MEDLINE | ID: mdl-23153540

Subject(s)

Kruppel-Like Transcription Factors/genetics; Leukemia, Megakaryoblastic, Acute/genetics; Oncogene Proteins, Fusion/genetics; Repressor Proteins/genetics; Tumor Suppressor Proteins/genetics; Animals; Bone Morphogenetic Proteins/metabolism; Child; Chromosome Inversion; Chromosomes, Human, Pair 16; Drosophila/genetics; Drosophila/growth & development; Gene Expression Profiling; Humans; Leukemia, Megakaryoblastic, Acute/classification; Leukemia, Megakaryoblastic, Acute/diagnosis; Mice; Oncogene Proteins, Fusion/metabolism; Oncogene Proteins, Fusion/physiology; Prognosis; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/physiology; Sequence Analysis, RNA; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Leukemia, Megakaryoblastic, Acute / Oncogene Proteins, Fusion / Tumor Suppressor Proteins / Kruppel-Like Transcription Factors Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Child / Humans Language: En Journal: Cancer Cell Year: 2012 Document type: Article

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