Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas.

Ciceroni, C; Bonelli, M; Mastrantoni, E; Niccolini, C; Laurenza, M; Larocca, L M; Pallini, R; Traficante, A; Spinsanti, P; Ricci-Vitiani, L; Arcella, A; De Maria, R; Nicoletti, F; Battaglia, G; Melchiorri, D

Ciceroni, C; Bonelli, M; Mastrantoni, E; Niccolini, C; Laurenza, M; Larocca, L M; Pallini, R; Traficante, A; Spinsanti, P; Ricci-Vitiani, L; Arcella, A; De Maria, R; Nicoletti, F; Battaglia, G; Melchiorri, D.

Affiliation

Ciceroni C; IRCCS San Raffaele Pisana, Rome, Italy.

Cell Death Differ ; 20(3): 396-407, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23175182

Subject(s)

Glioblastoma/metabolism; Neoplastic Stem Cells/metabolism; Receptors, Metabotropic Glutamate/metabolism; Amino Acids/toxicity; Animals; Antineoplastic Agents, Alkylating/pharmacology; Antineoplastic Agents, Alkylating/therapeutic use; Chemotherapy, Adjuvant; Combined Modality Therapy; DNA Methylation/drug effects; Dacarbazine/analogs & derivatives; Dacarbazine/pharmacology; Dacarbazine/therapeutic use; Drug Resistance, Neoplasm/drug effects; Glioblastoma/drug therapy; Glioblastoma/mortality; Humans; Mice; NF-kappa B/metabolism; Neoplastic Stem Cells/cytology; O(6)-Methylguanine-DNA Methyltransferase/genetics; O(6)-Methylguanine-DNA Methyltransferase/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Promoter Regions, Genetic; RNA, Messenger/metabolism; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Receptors, Metabotropic Glutamate/genetics; Signal Transduction; Survival Rate; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured; Xanthenes/toxicity

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Neoplastic Stem Cells / Receptors, Metabotropic Glutamate / Glioblastoma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Death Differ Year: 2013 Document type: Article

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