[Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia]. / Utilidad de la imagen precoz de la gammagrafía de inervación miocárdica en el diagnóstico de la demencia con cuerpos de Lewy.
Rev Esp Med Nucl Imagen Mol
; 32(2): 77-80, 2013 Mar.
Article
in Es
| MEDLINE
| ID: mdl-23177334
ABSTRACT
UNLABELLED The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac (123)I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment. The aim of this study was to assess the utility of early imaging of cardiac (123)I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. MATERIAL AND METHODS:
We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac (123)I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained.RESULTS:
After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%.CONCLUSIONS:
Early imaging of cardiac (123)I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognition Disorders
/
Radiopharmaceuticals
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Neurodegenerative Diseases
/
3-Iodobenzylguanidine
/
Lewy Body Disease
/
Heart
/
Iodine Radioisotopes
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Es
Journal:
Rev Esp Med Nucl Imagen Mol
Year:
2013
Document type:
Article