Cryopyrin-Associated Periodic Syndromes/immunology; Homeostasis/drug effects; Interleukin 1 Receptor Antagonist Protein/therapeutic use; Interleukin-1beta/genetics; Receptors, Interleukin-1/genetics; Skin/immunology; Adolescent; Adult; Antigens, CD/genetics; Antigens, CD/immunology; Biopsy; Caspase 1/genetics; Caspase 1/immunology; Child; Child, Preschool; Cryopyrin-Associated Periodic Syndromes/drug therapy; Cryopyrin-Associated Periodic Syndromes/genetics; Cryopyrin-Associated Periodic Syndromes/pathology; Epigenesis, Genetic/drug effects; Epigenesis, Genetic/immunology; Female; Gene Expression/drug effects; Gene Expression/immunology; HLA-DR Antigens/genetics; HLA-DR Antigens/immunology; Homeostasis/genetics; Homeostasis/immunology; Humans; Interleukin 1 Receptor Antagonist Protein/pharmacology; Interleukin-1beta/antagonists & inhibitors; Interleukin-1beta/immunology; Langerhans Cells/drug effects; Langerhans Cells/immunology; Langerhans Cells/pathology; Macrophages/drug effects; Macrophages/immunology; Macrophages/pathology; Male; MicroRNAs/genetics; MicroRNAs/immunology; Neutrophils/drug effects; Neutrophils/immunology; Neutrophils/pathology; Receptors, Interleukin-1/antagonists & inhibitors; Receptors, Interleukin-1/immunology; Signal Transduction/drug effects; Skin/drug effects; Skin/pathology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; T-Lymphocytes/pathology