Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system.

Keipert, S; Ost, M; Chadt, A; Voigt, A; Ayala, V; Portero-Otin, M; Pamplona, R; Al-Hasani, H; Klaus, S

Keipert, S; Ost, M; Chadt, A; Voigt, A; Ayala, V; Portero-Otin, M; Pamplona, R; Al-Hasani, H; Klaus, S.

Affiliation

Keipert S; German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany.

Am J Physiol Endocrinol Metab ; 304(5): E495-506, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23277187

Subject(s)

Antioxidants/metabolism; Longevity/physiology; Muscle, Skeletal/metabolism; Muscle, Skeletal/physiology; Aconitate Hydratase/metabolism; Animals; Biomarkers; Body Composition/drug effects; Body Composition/genetics; Body Composition/physiology; Catalase/blood; Dietary Fats/adverse effects; Fatty Acids/metabolism; Insulin Resistance/physiology; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mitogen-Activated Protein Kinases/metabolism; Muscle Proteins/biosynthesis; Muscle Proteins/genetics; Oxidation-Reduction; Oxidative Stress/drug effects; Oxidative Stress/physiology; Real-Time Polymerase Chain Reaction; Superoxide Dismutase/metabolism; Triglycerides/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Longevity / Antioxidants Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Year: 2013 Document type: Article

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