The genotoxicity of PEI-based nanoparticles is reduced by acetylation of polyethylenimine amines in human primary cells.

Calarco, Anna; Bosetti, Michela; Margarucci, Sabrina; Fusaro, Luca; Nicolì, Elena; Petillo, Orsolina; Cannas, Mario; Galderisi, Umberto; Peluso, Gianfranco

Calarco, Anna; Bosetti, Michela; Margarucci, Sabrina; Fusaro, Luca; Nicolì, Elena; Petillo, Orsolina; Cannas, Mario; Galderisi, Umberto; Peluso, Gianfranco.

Affiliation

Calarco A; Institute of Protein Biochemistry, CNR, Naples, Italy.

Toxicol Lett ; 218(1): 10-7, 2013 Mar 27.

Article in En | MEDLINE | ID: mdl-23296103

Subject(s)

Coated Materials, Biocompatible/toxicity; Human Umbilical Vein Endothelial Cells/drug effects; Mutagens/toxicity; Nanoparticles/toxicity; Polyethylene Glycols/toxicity; Polyethyleneimine/toxicity; Acetylation; Cell Survival/drug effects; Cells, Cultured; Coated Materials, Biocompatible/chemistry; Coated Materials, Biocompatible/metabolism; DNA/drug effects; DNA Damage; Dose-Response Relationship, Drug; Drug Carriers/chemistry; Drug Carriers/metabolism; Human Umbilical Vein Endothelial Cells/metabolism; Humans; Mutagens/chemistry; Mutagens/metabolism; Nanoparticles/chemistry; Polyethylene Glycols/chemistry; Polyethylene Glycols/metabolism; Polyethyleneimine/chemistry; Polyethyleneimine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Polyethyleneimine / Coated Materials, Biocompatible / Nanoparticles / Human Umbilical Vein Endothelial Cells / Mutagens Limits: Humans Language: En Journal: Toxicol Lett Year: 2013 Document type: Article

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