Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production.

Velegraki, Maria; Papakonstanti, Evaggelia; Mavroudi, Irene; Psyllaki, Maria; Tsatsanis, Christos; Oulas, Anastasis; Iliopoulos, Ioannis; Katonis, Pavlos; Papadaki, Helen A

Velegraki, Maria; Papakonstanti, Evaggelia; Mavroudi, Irene; Psyllaki, Maria; Tsatsanis, Christos; Oulas, Anastasis; Iliopoulos, Ioannis; Katonis, Pavlos; Papadaki, Helen A.

Affiliation

Velegraki M; Department of Hematology, University of Crete School of Medicine, Heraklion, Greece.

Haematologica ; 98(8): 1206-15, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23403315

Subject(s)

Apoptosis/immunology; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; HMGB1 Protein/metabolism; Myelodysplastic Syndromes/metabolism; Myelodysplastic Syndromes/pathology; Toll-Like Receptor 4/physiology; Aged; Aged, 80 and over; Cells, Cultured; Coculture Techniques; Cross-Over Studies; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes/immunology; Toll-Like Receptor 4/biosynthesis

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Myelodysplastic Syndromes / Bone Marrow Cells / Apoptosis / HMGB1 Protein / Toll-Like Receptor 4 Type of study: Clinical_trials Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Haematologica Year: 2013 Document type: Article

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