Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.

Branchu, Julien; Biondi, Olivier; Chali, Farah; Collin, Thibault; Leroy, Felix; Mamchaoui, Kamel; Makoukji, Joelle; Pariset, Claude; Lopes, Philippe; Massaad, Charbel; Chanoine, Christophe; Charbonnier, Frédéric

Branchu, Julien; Biondi, Olivier; Chali, Farah; Collin, Thibault; Leroy, Felix; Mamchaoui, Kamel; Makoukji, Joelle; Pariset, Claude; Lopes, Philippe; Massaad, Charbel; Chanoine, Christophe; Charbonnier, Frédéric.

Affiliation

Branchu J; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8194, Université Paris Descartes, F-75270 Paris, France.

J Neurosci ; 33(10): 4280-94, 2013 Mar 06.

Article in En | MEDLINE | ID: mdl-23467345

Subject(s)

Cyclic AMP Response Element-Binding Protein/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Motor Neurons/physiology; Muscular Atrophy, Spinal/pathology; Signal Transduction/physiology; Animals; Animals, Newborn; Butadienes/pharmacology; Calcium/metabolism; Cell Survival/physiology; Cells, Cultured; Chromatin Immunoprecipitation; Coculture Techniques/methods; Cyclic AMP Response Element-Binding Protein/genetics; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Exploratory Behavior/drug effects; Extracellular Signal-Regulated MAP Kinases/genetics; Female; Ganglia, Spinal/cytology; Humans; Male; Mice; Mice, Knockout; Motor Neurons/drug effects; Motor Neurons/pathology; Muscle Cells/drug effects; Muscle Cells/physiology; N-Methylaspartate/pharmacology; Nitriles/pharmacology; Signal Transduction/drug effects; Signal Transduction/genetics; Stem Cells/drug effects; Stem Cells/physiology; Survival of Motor Neuron 2 Protein/deficiency

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscular Atrophy, Spinal / Signal Transduction / Cyclic AMP Response Element-Binding Protein / Extracellular Signal-Regulated MAP Kinases / Motor Neurons Type of study: Prognostic_studies Language: En Journal: J Neurosci Year: 2013 Document type: Article

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