Changes in brain cortex sensitivity to epileptogens under conditions of ketogenic diet.

ABSTRACT

The epileptogenic effects of applications of NMDA and kainic acid solutions to the frontal cortex were attenuated in rats receiving ketogenic diet (80% lipids, 3.3% carbohydrates, and 16.7% proteins) during 4 weeks. Spike latency increased, the power of focal epileptic activity decreased, and focus lifetime was shortened in these animals. Sodium benzylpenicillin and strychnine nitrate less markedly reduced epileptogenic activity.