Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice.

Masuelli, L; Benvenuto, M; Fantini, M; Marzocchella, L; Sacchetti, P; Di Stefano, E; Tresoldi, I; Izzi, V; Bernardini, R; Palumbo, C; Mattei, M; Lista, F; Galvano, F; Modesti, A; Bei, R

Masuelli, L; Benvenuto, M; Fantini, M; Marzocchella, L; Sacchetti, P; Di Stefano, E; Tresoldi, I; Izzi, V; Bernardini, R; Palumbo, C; Mattei, M; Lista, F; Galvano, F; Modesti, A; Bei, R.

Affiliation

Masuelli L; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

J Biol Regul Homeost Agents ; 27(1): 105-19, 2013.

Article in En | MEDLINE | ID: mdl-23489691

Subject(s)

Apoptosis/drug effects; Breast Neoplasms/pathology; Curcumin/pharmacology; Mammary Neoplasms, Animal/pathology; Receptor, ErbB-2/metabolism; Animals; Breast Neoplasms/drug therapy; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Curcumin/adverse effects; Curcumin/therapeutic use; Drug Screening Assays, Antitumor; Female; Fibroblasts/drug effects; Fibroblasts/metabolism; Fibroblasts/pathology; Humans; MAP Kinase Signaling System/drug effects; Mammary Neoplasms, Animal/blood; Mammary Neoplasms, Animal/drug therapy; Mice; Mice, Inbred BALB C; Mice, Transgenic; NIH 3T3 Cells; Phosphorylation/drug effects; Poly(ADP-ribose) Polymerases/metabolism; Rats; Receptor, ErbB-2/genetics; bcl-2-Associated X Protein/metabolism

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Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Breast Neoplasms / Mammary Neoplasms, Animal / Apoptosis / Receptor, ErbB-2 / Curcumin Limits: Animals / Female / Humans Language: En Journal: J Biol Regul Homeost Agents Year: 2013 Document type: Article

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