Influence of microRNA deregulation on chaperone-mediated autophagy and &#945;-synuclein pathology in Parkinson's disease.

Alvarez-Erviti, L; Seow, Y; Schapira, A H V; Rodriguez-Oroz, M C; Obeso, J A; Cooper, J M

Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.

Alvarez-Erviti, L; Seow, Y; Schapira, A H V; Rodriguez-Oroz, M C; Obeso, J A; Cooper, J M.

Affiliation

Alvarez-Erviti L; Department of Clinical Neuroscience, Institute of Neurology, University College London, London, UK.

Cell Death Dis ; 4: e545, 2013 Mar 14.

Article in En | MEDLINE | ID: mdl-23492776

Subject(s)

HSP70 Heat-Shock Proteins/genetics; Lewy Bodies/genetics; Lysosomal Membrane Proteins/genetics; MicroRNAs/genetics; Parkinson Disease/genetics; alpha-Synuclein/genetics; Amygdala/metabolism; Amygdala/pathology; Autophagy; Cell Line, Tumor; Gene Expression Regulation; Genes, Reporter; HSP70 Heat-Shock Proteins/metabolism; Humans; Lewy Bodies/metabolism; Lewy Bodies/pathology; Luciferases; Lysosomal-Associated Membrane Protein 2; Lysosomal Membrane Proteins/metabolism; MicroRNAs/metabolism; Parkinson Disease/metabolism; Parkinson Disease/pathology; Protein Isoforms/genetics; Protein Isoforms/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Signal Transduction; Substantia Nigra/metabolism; Substantia Nigra/pathology; Transcription, Genetic; alpha-Synuclein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Lewy Bodies / HSP70 Heat-Shock Proteins / MicroRNAs / Lysosomal Membrane Proteins / Alpha-Synuclein Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Death Dis Year: 2013 Document type: Article

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