Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.

Grimm, Melissa J; Vethanayagam, R Robert; Almyroudis, Nikolaos G; Dennis, Carly G; Khan, A Nazmul H; D'Auria, Anthony C; Singel, Kelly L; Davidson, Bruce A; Knight, Paul R; Blackwell, Timothy S; Hohl, Tobias M; Mansour, Michael K; Vyas, Jatin M; Röhm, Marc; Urban, Constantin F; Kelkka, Tiina; Holmdahl, Rikard; Segal, Brahm H

Grimm, Melissa J; Vethanayagam, R Robert; Almyroudis, Nikolaos G; Dennis, Carly G; Khan, A Nazmul H; D'Auria, Anthony C; Singel, Kelly L; Davidson, Bruce A; Knight, Paul R; Blackwell, Timothy S; Hohl, Tobias M; Mansour, Michael K; Vyas, Jatin M; Röhm, Marc; Urban, Constantin F; Kelkka, Tiina; Holmdahl, Rikard; Segal, Brahm H.

Affiliation

Grimm MJ; Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

J Immunol ; 190(8): 4175-84, 2013 Apr 15.

Article in En | MEDLINE | ID: mdl-23509361

Subject(s)

Aspergillus fumigatus/immunology; Macrophages, Alveolar/enzymology; Macrophages, Alveolar/immunology; Monocytes/enzymology; Monocytes/immunology; NADPH Oxidases/physiology; Acute Disease; Animals; Aspergillosis/enzymology; Aspergillosis/immunology; Aspergillosis/pathology; Genetic Predisposition to Disease; Inflammation/enzymology; Inflammation/microbiology; Inflammation/prevention & control; Lung/enzymology; Lung/immunology; Lung/microbiology; Macrophages, Alveolar/microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monocytes/microbiology; NADPH Oxidases/deficiency; NADPH Oxidases/genetics; Zymosan/pharmacology

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Aspergillus fumigatus / Monocytes / Macrophages, Alveolar / NADPH Oxidases Limits: Animals Language: En Journal: J Immunol Year: 2013 Document type: Article

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